• Research Article  31 March 2020

    Identification of cis-Regulatory Region Controlling Semaphorin-1a Expression in the Drosophila Embryonic Nervous System

    The Drosophila transmembrane semaphorin Sema-1a mediates forward and reverse signaling that plays an essential role in motor and central nervous system (CNS) axon pathfinding during embryonic neural development. Previous immunohistochemical analysis revealed that Sema-1a is expressed on most commissural and longitudinal axons in the CNS and five motor nerve branches in the peripheral nervous system (PNS). However, Sema-1a-mediated axon guidance function contributes significantly to both i ...

  • Rapid Report  31 March 2020

    Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning

    Inositol polyphosphate multikinase (IPMK) is required for the biosynthesis of inositol phosphates (IPs) through the phosphorylation of multiple IP metabolites such as IP3 and IP4. The biological significance of IPMK’s catalytic actions to regulate cellular signaling events such as growth and metabolism has been studied extensively. However, pharmacological reagents that inhibit IPMK have not yet been identified. We employed a structure-based virtual screening of publicly available U.S. Food an ...

  • Minireview  31 March 2020

    Distinct Developmental Features of Olfactory Bulb Interneurons

    The olfactory bulb (OB) has an extremely higher proportion of interneurons innervating excitatory neurons than other brain regions, which is evolutionally conserved across species.Despite the abundance of OB interneurons, little is known about the diversification and physiological functions of OB interneurons compared to cortical interneurons. In this review, an overview of the general developmental process of interneurons from the angles of the spatial and temporal specifications was presented. ...

  • Minireview  31 March 2020

    Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders

    Post-translational modifications play major roles in the stability, function, and localization of target proteins involved in the nervous system. The ubiquitin-proteasome pathway uses small ubiquitin molecules to degrade neuronal proteins. Deubiquitinating enzymes (DUBs) reverse this degradation and thereby control neuronal cell fate, synaptic plasticity,axonal growth, and proper function of the nervous system.Moreover, mutations or downregulation of certain DUBshave been found in several neurod ...


Mol. Cells 2020; 43(3): 203~311
Minireviews
Critical Roles of Deubiquitinating Enzymes in the Nervous System and Neurodegenerative Disorders
Soumyadip Das , Suresh Ramakrishna , and Kye-Seong Kim
Mol. Cells 2020; 43(3): 203-214  https://doi.org/10.14348/molcells.2020.2289 PDF PubMed Google Scholar Search
Distinct Developmental Features of Olfactory Bulb Interneurons
Jae Yeon Kim , Jiyun Choe , and Cheil Moon
Mol. Cells 2020; 43(3): 215-221  https://doi.org/10.14348/molcells.2020.0033 PDF PubMed Google Scholar Search
Rapid Report
Identification of the Antidepressant Vilazodone as an Inhibitor of Inositol Polyphosphate Multikinase by Structure-Based Drug Repositioning
Boah Lee , Seung Ju Park , Seulgi Lee , Seung Eun Park , Eunhye Lee , Ji-Joon Song , Youngjoo Byun , and Seyun Kim
Mol. Cells 2020; 43(3): 222-227  https://doi.org/10.14348/molcells.2020.0051 PDF PubMed Supplementary File(s) Google Scholar Search
Research Articles
Identification of cis-Regulatory Region Controlling Semaphorin-1a Expression in the Drosophila Embryonic Nervous System
Young Gi Hong , Bongsu Kang , Seongsoo Lee , Youngseok Lee , Bong-Gun Ju , and Sangyun Jeong
Mol. Cells 2020; 43(3): 228-235  https://doi.org/10.14348/molcells.2019.0294 PDF PubMed Supplementary File(s) Google Scholar Search
Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under Nutrient/Serum Starvation
Zolzaya Sandag , Samil Jung , Nguyen Thi Ngoc Quynh , Davaajargal Myagmarjav , Nguyen Hai Anh , Dan-Diem Thi Le , Beom Suk Lee , Raj Kumar Mongre , Taeyeon Jo , and MyeongSok Lee
Mol. Cells 2020; 43(3): 236-250  https://doi.org/10.14348/molcells.2020.2193 PDF PubMed Google Scholar Search
Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses
Wondae Kang , Areum Park , Ji-Won Huh , Gihoon You , Da-Jung Jung , Manki Song , Heung Kyu Lee , and You-Me Kim
Mol. Cells 2020; 43(3): 251-263  https://doi.org/10.14348/molcells.2020.2300 PDF PubMed Supplementary File(s) Google Scholar Search
Reduced EGFR Level in eIF2α Phosphorylation-Deficient Hepatocytes Is Responsible for Susceptibility to Oxidative Stress
Mi-Jeong Kim , Woo-Gyun Choi , Kyung-Ju Ahn , In Gyeong Chae , Rina Yu , and Sung Hoon Back
Mol. Cells 2020; 43(3): 264-275  https://doi.org/10.14348/molcells.2020.2197 PDF PubMed Supplementary File(s) Google Scholar Search
Gut Microbial Metabolites Induce Changes in Circadian Oscillation of Clock Gene Expression in the Mouse Embryonic Fibroblasts
Kyojin Ku , Inah Park, Doyeon Kim , Jeongah Kim, Sangwon Jang, Mijung Choi, Han Kyoung Choe , and Kyungjin Kim
Mol. Cells 2020; 43(3): 276-285  https://doi.org/10.14348/molcells.2020.2309 PDF PubMed Google Scholar Search
Interaction of the Lysophospholipase PNPLA7 with Lipid Droplets through the Catalytic Region
Pingan Chang , Tengteng Sun , Christoph Heier , Hao Gao , Hongmei Xu , and Feifei Huang
Mol. Cells 2020; 43(3): 286-297  https://doi.org/10.14348/molcells.2020.2283 PDF PubMed Google Scholar Search
Real-Time Measurement of the Liquid Amount in Cryo-Electron Microscopy Grids Using Laser Diffraction of Regular 2-D Holes of the Grids
Jinsook Ahn , Dukwon Lee , Inseong Jo , Hyeongseop Jeong , Jae-Kyung Hyun , Jae-Sung Woo , Sang-Ho Choi , and Nam-Chul Ha
Mol. Cells 2020; 43(3): 298-303  https://doi.org/10.14348/molcells.2020.2238 PDF PubMed Supplementary File(s) Google Scholar Search
Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila
Yoon Seok Suh , Eunbyul Yeom , Jong-Woo Nam, Kyung-Jin Min , Jeongsoo Lee , and Kweon Yu
Mol. Cells 2020; 43(3): 304-311  https://doi.org/10.14348/molcells.2019.0273 PDF PubMed Supplementary File(s) Google Scholar Search
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Current Issue

31 March 2020
Volume 43,
Number 3,
pp. 203~311
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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