• Research Article  30 June 2019

    Heterogeneous Sequences of Brain Cytoplasmic 200 RNA Formed by Multiple Adenine Nucleotide Insertions

    Brain cytoplasmic 200 RNA (BC200 RNA), originally identified as a neuron-specific non-coding RNA, is also observed in various cancer cells that originate from non-neural cells. Studies have revealed diverse functions of BC200 RNA in cancer cells. Accordingly, we hypothesized that BC200 RNA might be modified in cancer cells to generate cancerous BC200 RNA responsible for its cancer-specific functions. Here, we report that BC200 RNA sequences are highly heterogeneous in cancer cells by virtue o ...

  • Research Article  30 June 2019

    Crystal Structure of a Highly Thermostable α-Carbonic Anhydrase from Persephonella marina EX-H1

    Bacterial α-type carbonic anhydrase (α-CA) is a zinc metalloenzyme that catalyzes the reversible and extremely rapid interconversion of carbon dioxide to bicarbonate. In this study, we report the first crystal structure of a hyperthermostable α-CA from Persephonella marina EX-H1 (pmCA) in the absence and presence of competitive inhibitor, acetazolamide. The structure reveals a compactly folded pmCA homodimer in which each monomer consists ...

  • Research Article  30 June 2019

    Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein–Barr Virus-Infected Gastric Cancer Cells

    The phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway is a promising target for gastric cancer (GC) treatment; however the efficacy of PI3K/mTOR dual inhibitors in GC has not yet been maximized. Additionally, the effect of autophagy regulation by PI3K/mTOR dual inhibitors has not been clearly elucidated in GC treatment. We aimed to show that our newly developed PI3K/mTOR dual inhibitor, CMG002, when combined with an autophagy inhibitor, ...

  • Minireview  30 June 2019

    Neurodevelopmental Aspects of RASopathies

    RAS gene mutations are frequently found in one third of human cancers. Affecting approximately 1 in 1,000 newborns, germline and somatic gain-of-function mutations in the components of RAS/mitogen-activated protein kinase (RAS/MAPK) pathway has been shown to cause developmental disorders, known as RASopathies. Since RAS-MAPK pathway plays essential roles in proliferation, differentiation and migration involving developmental processes, individuals with RASopathies show abnorm ...


Mol. Cells 2019; 42(6): 441~501
Minireview
Neurodevelopmental Aspects of RASopathies
Ye Eun Kim and Seung Tae Baek
Mol. Cells 2019; 42(6): 441-447  https://doi.org/10.14348/molcells.2019.0037 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
Combination Therapy with a PI3K/mTOR Dual Inhibitor and Chloroquine Enhances Synergistic Apoptotic Cell Death in Epstein–Barr Virus-Infected Gastric Cancer Cells
Mi-Young Kim, Annie J. Kruger, Ju-Yeon Jeong, Jaehee Kim, Phil kyung Shin, Sun Young Kim, Joo Young Cho, Ki Baik Hahm, and Sung Pyo Hong
Mol. Cells 2019; 42(6): 448-459  https://doi.org/10.14348/molcells.2019.2395 PDF PubMed PubMed Central Supplementary File(s) Supplementary File(s) Google Scholar Search
Crystal Structure of a Highly Thermostable α-Carbonic Anhydrase from Persephonella marina EX-H1
Subin Kim, Jongmin Sung, Jungyoon Yeon, Seung Hun Choi, and Mi Sun Jin
Mol. Cells 2019; 42(6): 460-469  https://doi.org/10.14348/molcells.2019.0029 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
The Mechanism of Action of Ghrelin and Motilin in the Pacemaker Potentials of Interstitial Cells of Cajal from the Murine Small Intestine
Jeong Nam Kim and Byung Joo Kim
Mol. Cells 2019; 42(6): 470-479  https://doi.org/10.14348/molcells.2019.0028 PDF PubMed PubMed Central PubReader Google Scholar Search
Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates
Sangwoo Ham, Hyojung Kim, Seojin Hwang, Hyunook Kang, Seung Pil Yun, Sangjune Kim, Donghoon Kim, Hyun Sook Kwon, Yun-Song Lee, MyoungLae Cho, Heung-Mook Shin, Heejung Choi, Ka Young Chung, Han Seok Ko, Gum Hwa Lee, and Yunjong Lee
Mol. Cells 2019; 42(6): 480-494  https://doi.org/10.14348/molcells.2019.0091 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Heterogeneous Sequences of Brain Cytoplasmic 200 RNA Formed by Multiple Adenine Nucleotide Insertions
Heegwon Shin, Jungmin Lee, Youngmi Kim, Seonghui Jang, Meehyein Kim, and Younghoon Lee
Mol. Cells 2019; 42(6): 495-500  https://doi.org/10.14348/molcells.2019.0108 PDF PubMed PubMed Central PubReader Google Scholar Search
Erratum
Erratum to: Roles of Endoplasmic Reticulum Stress in Immune Responses
Jae-Seon So
Mol. Cells 2019; 42(6): 501-501  https://doi.org/10.14348/molcells.2019.1241 PDF PubMed PubMed Central Google Scholar Search
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Current Issue

30 June 2019
Volume 42,
Number 6,
pp. 441~501
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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