• Research Article  31 March 2021

    Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity

    The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking. Thus, we deleted tumor susceptibility gene 101 (Tsg101), a key component of endosomal sorting co ...

  • Research Article  31 March 2021

    Morphological Characterization of small, dumpy, and long Phenotypes in Caenorhabditis elegans

    The determinant factors of an organism’s size during animal development have been explored from various angles but remain partially understood. In Caenorhabditis elegans, many genes affecting cuticle structure, cell growth, and proliferation have been identified to regulate the worm’s overall morphology, including body size. While various mutations in those genes directly result in changes in the morphological phenotypes, there is still a need for established, clear, and distinct stan ...

  • Research Article  31 March 2021

    Crystal Structure of the Pneumococcal Vancomycin-Resistance Response Regulator DNA-Binding Domain

    Vancomycin response regulator (VncR) is a pneumococcal response regulator of the VncRS two-component signal transduction system (TCS) of Streptococcus pneumoniae. VncRS regulates bacterial autolysis and vancomycin resistance. VncR contains two different functional domains, the N-terminal receiver domain and C-terminal effector domain. Here, we investigated VncR C-terminal DNA binding domain (VncRc) structure using a crystallization approach. Crystallization was performed using the micro-batch me ...

  • Minireview  31 March 2021

    Transcriptomic Analysis of Cellular Senescence: One Step Closer to Senescence Atlas

    Senescent cells that gradually accumulate during aging are one of the leading causes of aging. While senolytics can improve aging in humans as well as mice by specifically eliminating senescent cells, the effect of the senolytics varies in different cell types, suggesting variations in senescence. Various factors can induce cellular senescence, and the rate of accumulation of senescent cells differ depending on the organ. In addition, since the heterogeneity is due to the spatiotemporal context ...

  • Minireview  31 March 2021

    Single-Cell Toolkits Opening a New Era for Cell Engineering

    Since the introduction of RNA sequencing (RNA-seq) as a high-throughput mRNA expression analysis tool, this procedure has been increasingly implemented to identify cell-level transcriptome changes in a myriad of model systems. However, early methods processed cell samples in bulk, and therefore the unique transcriptomic patterns of individual cells would be lost due to data averaging. Nonetheless, the recent and continuous development of new single-cell RNA sequencing (scRNA-seq) toolkits has en ...


Mol. Cells 2021; 44(3): 127~185
Minireviews
Single-Cell Toolkits Opening a New Era for Cell Engineering
Sean Lee , Jireh Kim , and Jong-Eun Park
Mol. Cells 2021; 44(3): 127-135  https://doi.org/10.14348/molcells.2021.0002 PDF PubMed Google Scholar Search
Transcriptomic Analysis of Cellular Senescence: One Step Closer to Senescence Atlas
Sohee Kim and Chuna Kim
Mol. Cells 2021; 44(3): 136-145  https://doi.org/10.14348/molcells.2021.2239 PDF PubMed Google Scholar Search
Research Articles
UHRF1 Induces Methylation of the TXNIP Promoter and Down-Regulates Gene Expression in Cervical Cancer
Min Jun Kim , Han Ju Lee , Mee Young Choi , Sang Soo Kang , Yoon Sook Kim , Jeong Kyu Shin , and Wan Sung Choi
Mol. Cells 2021; 44(3): 146-159  https://doi.org/10.14348/molcells.2021.0001 PDF PubMed Supplementary File(s) Google Scholar Search
Morphological Characterization of small, dumpy, and long Phenotypes in Caenorhabditis elegans
Joshua Young Cho , Tae-Woo Choi , Seung Hyun Kim , Joohong Ahnn , and Sun-Kyung Lee
Mol. Cells 2021; 44(3): 160-167  https://doi.org/10.14348/molcells.2021.2236 PDF PubMed Supplementary File(s) Google Scholar Search
Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity
Dai Le , Soyeon Lim , Kwang Wook Min , Joon Woo Park , Youjoung Kim , Taejeong Ha , Kyeong Hwan Moon , Kay-Uwe Wagner , and Jin Woo Kim
Mol. Cells 2021; 44(3): 168-178  https://doi.org/10.14348/molcells.2021.0027 PDF PubMed Supplementary File(s) Google Scholar Search
Crystal Structure of the Pneumococcal Vancomycin-Resistance Response Regulator DNA-Binding Domain
Sang-Sang Park , Sangho Lee , and Dong-Kwon Rhee
Mol. Cells 2021; 44(3): 179-185  https://doi.org/10.14348/molcells.2021.2235 PDF PubMed Google Scholar Search
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Current Issue

31 March 2021
Volume 44,
Number 3,
pp. 127~185
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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