• Research Article  31 July 2019

    Identification of Protein Phosphatase 4 Inhibitory Protein That Plays an Indispensable Role in DNA Damage Response

    Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status ...

  • Research Article  31 July 2019

    Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma

    Tumor cells can vary epigenetically during ionizing irradiation (IR) treatment. These epigenetic variegations can influence IR response and shape tumor aggressiveness. However, epigenetic disturbance of histones after IR, implicating in IR responsiveness, has been elusive. Here, we investigate whether altered histone modification after IR can influence radiation responsiveness. The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopi ...

  • Research Article  31 July 2019

    Nuclear UPF1 Is Associated with Chromatin for Transcription-Coupled RNA Surveillance

    mRNA quality is controlled by multiple RNA surveillance machineries to reduce errors during gene expression processes in eukaryotic cells. Nonsense-mediated mRNA decay (NMD) is a well-characterized mechanism that degrades error-containing transcripts during translation. The ATP-dependent RNA helicase up-frameshift 1 (UPF1) is a key player in NMD that is mostly prevalent in the cytoplasm. However, recent studies on UPF1-RNA interaction suggest more comprehensive roles of UPF1 on diverse forms ...

  • Minireview  31 July 2019

    Characterization of Structural Variations in the Context of 3D Chromatin Structure

    Chromosomes located in the nucleus form discrete units of genetic material composed of DNA and protein complexes. The genetic information is encoded in linear DNA sequences, but its interpretation requires an understanding of three-dimensional (3D) structure of the chromosome, in which distant DNA sequences can be juxtaposed by highly condensed chromatin packing in the space of nucleus to precisely control gene expression. Recent technological innovations in exploring higher-order chromatin s ...


Mol. Cells 2019; 42(7): 503~567
Minireviews
Role of RIN4 in Regulating PAMP-Triggered Immunity and Effector-Triggered Immunity: Current Status and Future Perspectives
Sujit Kumar Ray, Donah Mary Macoy, Woe-Yeon Kim, Sang Yeol Lee, and Min Gab Kim
Mol. Cells 2019; 42(7): 503-511  https://doi.org/10.14348/molcells.2019.2433 PDF PubMed PubMed Central PubReader Google Scholar Search
Characterization of Structural Variations in the Context of 3D Chromatin Structure
Kyukwang Kim, Junghyun Eom, and Inkyung Jung
Mol. Cells 2019; 42(7): 512-522  https://doi.org/10.14348/molcells.2019.0137 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
Nuclear UPF1 Is Associated with Chromatin for Transcription-Coupled RNA Surveillance
Dawon Hong, Taeyoung Park, and Sunjoo Jeong
Mol. Cells 2019; 42(7): 523-529  https://doi.org/10.14348/molcells.2019.0116 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma
Hak Jun Ahn, Soon Young Hwang, Ngoc Hoan Nguyen, Ik Jae Lee, Eun Jeong Lee, Jinsil Seong, and Jong-Soo Lee
Mol. Cells 2019; 42(7): 530-545  https://doi.org/10.14348/molcells.2019.2280 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Identification of Protein Phosphatase 4 Inhibitory Protein That Plays an Indispensable Role in DNA Damage Response
Jaehong Park, Jihye Lee, and Dong-Hyun Lee
Mol. Cells 2019; 42(7): 546-556  https://doi.org/10.14348/molcells.2019.0014 PDF PubMed PubMed Central PubReader Google Scholar Search
TSPAN12 Precedes Tumor Proliferation by Cell Cycle Control in Ovarian Cancer
Guohua Ji, Hongbin Liang, Falin Wang, Nan Wang, Songbin Fu, and Xiaobo Cui
Mol. Cells 2019; 42(7): 557-567  https://doi.org/10.14348/molcells.2019.0015 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
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Current Issue

31 July 2019
Volume 42,
Number 7,
pp. 503~567
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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