• Article  31 March 2019

    Knockdown of lncRNA PVT1 Inhibits Vascular Smooth Muscle Cell Apoptosis and Extracellular Matrix Disruption in a Murine Abdominal Aortic Aneurysm Model

    This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. After injection of PVT1-silencing lentiviruses, AAA was induced in Apolipoprotein E-deficient (ApoE−/−) male mice by angiotensin II (Ang II) infusion for four weeks. After Ang II ...

  • Article  31 March 2019

    Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models

    The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. However, it remains elusive whether this mechanism is also applicable to senescence amelioration in accelerated aging cells. In this study, we examined the role of ATM inhibiti ...

  • Article  31 March 2019

    Segmented Filamentous Bacteria Induce Divergent Populations of Antigen-Specific CD4 T Cells in the Small Intestine

    CD4 T cells differentiate into RORγt/IL-17A-expressing cells in the small intestine following colonization by segmented filamentous bacteria (SFB). However, it remains unclear whether SFB-specific CD4 T cells can differentiate directly from naïve precursors, and whether their effector differentiation is solely directed towards the Th17 lineage. In this study, we used adoptive T cell transfer experiments and showed that naïve CD4 T cells can migrate to the small intestinal lamina propria (s ...

  • Minireview  31 March 2019

    Dissecting Cellular Heterogeneity Using Single-Cell RNA Sequencing

    Cell-to-cell variability in gene expression exists even in a homogeneous population of cells. Dissecting such cellular heterogeneity within a biological system is a prerequisite for understanding how a biological system is developed, homeo-statically regulated, and responds to external perturbations. Single-cell RNA sequencing (scRNA-seq) allows the quantitative and unbiased characterization of cellular heterogeneity by providing genome-wide molecular profiles from tens of thousands of indivi ...


Mol. Cells 2019; 42(3): 189~283
Minireviews
Dissecting Cellular Heterogeneity Using Single-Cell RNA Sequencing
Yoon Ha Choi, and Jong Kyoung Kim
Mol. Cells 2019; 42(3): 189-199  https://doi.org/10.14348/molcells.2019.2446 PDF PubReader Google Scholar Search
Directed Differentiation of Pluripotent Stem Cells by Transcription Factors
Yujeong Oh, and Jiwon Jang
Mol. Cells 2019; 42(3): 200-209  https://doi.org/10.14348/molcells.2019.2439 PDF PubReader Google Scholar Search
Articles
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
Myeong Uk Kuk, Jae Won Kim, Young-Sam Lee, Kyung A Cho, Joon Tae Park, and Sang Chul Park
Mol. Cells 2019; 42(3): 210-217  https://doi.org/10.14348/molcells.2018.0352 PDF PubReader Supplementary File(s) Google Scholar Search
Knockdown of lncRNA PVT1 Inhibits Vascular Smooth Muscle Cell Apoptosis and Extracellular Matrix Disruption in a Murine Abdominal Aortic Aneurysm Model
Zhidong Zhang, Gangqiang Zou, Xiaosan Chen, Wei Lu, Jianyang Liu, Shuiting Zhai, and Gang Qiao
Mol. Cells 2019; 42(3): 218-227  https://doi.org/10.14348/molcells.2018.0162 PDF PubReader Google Scholar Search
Segmented Filamentous Bacteria Induce Divergent Populations of Antigen-Specific CD4 T Cells in the Small Intestine
Jaeu Yi, Jisun Jung, Daehee Han, Charles D. Surh, and You Jeong Lee
Mol. Cells 2019; 42(3): 228-236  https://doi.org/10.14348/molcells.2018.0424 PDF PubReader Google Scholar Search
CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures
Su-Kyeong Jang, Byung-Ha Yoon, Seung Min Kang, Yeo-Gha Yoon, Seon-Young Kim, and Wankyu Kim
Mol. Cells 2019; 42(3): 237-244  https://doi.org/10.14348/molcells.2018.0413 PDF PubReader Supplementary File(s) Google Scholar Search
Ependymal Cells Require Anks1a for Their Proper Development
Sunjung Park, Haeryung Lee, Jiyeon Lee, Eunjeong Park, and Soochul Park
Mol. Cells 2019; 42(3): 245-251  https://doi.org/10.14348/molcells.2018.0432 PDF PubReader Google Scholar Search
G-Protein-Coupled Receptor 120 Mediates DHA-Induced Apoptosis by Regulating IP3R, ROS and, ER Stress Levels in Cisplatin-Resistant Cancer Cells
Jong-Il Shin, Yong-Joon Jeon, Sol Lee, Yoon Gyeong Lee, Ji Beom Kim, and Kyungho Lee
Mol. Cells 2019; 42(3): 252-261  https://doi.org/10.14348/molcells.2019.2440 PDF PubReader Google Scholar Search
Enhanced Expression and Functional Characterization of the Recombinant Putative Lysozyme-PMAP36 Fusion Protein
Zhili Rao, So Young Kim, Md Rashedunnabi Akanda, Su Jin Lee, In Duk Jung, Byung-Yong Park, Seralathan Kamala-Kannan, Jin Hur, and Jung Hee Park
Mol. Cells 2019; 42(3): 262-269  https://doi.org/10.14348/molcells.2019.2365 PDF PubReader Supplementary File(s) Google Scholar Search
LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis
Tian Yang, Hong Li, Tianjun Chen, Hui Ren, Puyu Shi, and Mingwei Chen
Mol. Cells 2019; 42(3): 270-283  https://doi.org/10.14348/molcells.2019.2364 PDF PubReader Google Scholar Search
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Current Issue

31 March 2019
Volume 42,
Number 3,
pp. 189~283
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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