• Minireview  31 May 2021

    Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages

    Tissue-resident macrophages play an important role in maintaining tissue homeostasis and innate immune defense against invading microbial pathogens. Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, also known as central nervous system-associated or border-associated macrophages, in the brain-circulation interface. Microglia and non-parenchymal brain macrophages, including meningeal, perivascular, and choroid plexus macroph ...

  • Minireview  31 May 2021

    Development and Functions of Alveolar Macrophages

    Macrophages residing in various tissue types are unique in terms of their anatomical locations, ontogenies, developmental pathways, gene expression patterns, and immunological functions. Alveolar macrophages (AMs) reside in the alveolar lumen of the lungs and serve as the first line of defense for the respiratory tract. The immunological functions of AMs are implicated in the pathogenesis of various pulmonary diseases such as allergic asthma, chronic obstructive pulmonary disorder (COPD), pulmon ...

  • Minireview  31 May 2021

    Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis

    Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting ...

  • Minireview  31 May 2021

    Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System

    Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms. CD1a is distinguished by the small volume of its antigen-binding groove and its stunted A′ pocket, its high and exclusive expression on Langerhans cells, and its localization in the early endosomal and recycling intracellular trafficking compartments. Its ligands originate from self or foreign sources. There are three modes by which the T-cell rece ...

  • Minireview  31 May 2021

    Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation

    CD4+ T helper (Th) cells play a crucial role in the modulation of innate and adaptive immune responses through the differentiation of Th precursor cells into several subsets, including Th1, Th2, Th17, and regulatory T (Treg) cells. Effector Th and Treg cells are distinguished by the production of signature cytokines and are important for eliminating intracellular and extracellular pathogens and maintaining immune homeostasis. Stimulation of naïve Th cells by T cell receptor and specific cytokin ...


Mol. Cells 2021; 44(5): 279~373
Editorial
Immune Networks in Health and Disease
Heung Kyu Lee and Doo Hyun Chung
Mol. Cells 2021; 44(5): 279-280  https://doi.org/10.14348/molcells.2021.0117 PDF PubMed PubMed Central Google Scholar Search
Minireviews
Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages
Eunju Lee , Jun-Cheol Eo , Changjun Lee , and Je-Wook Yu
Mol. Cells 2021; 44(5): 281-291  https://doi.org/10.14348/molcells.2021.0060 PDF PubMed PubMed Central Google Scholar Search
Development and Functions of Alveolar Macrophages
Yeon Duk Woo , Dongjin Jeong , and Doo Hyun Chung
Mol. Cells 2021; 44(5): 292-300  https://doi.org/10.14348/molcells.2021.0058 PDF PubMed PubMed Central Google Scholar Search
Innate Lymphoid Cells in Tissue Homeostasis and Disease Pathogenesis
Jihyun Kim , Seungwon Ryu , and Hye Young Kim
Mol. Cells 2021; 44(5): 301-309  https://doi.org/10.14348/molcells.2021.0053 PDF PubMed PubMed Central Google Scholar Search
Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System
Hyun Jung Yoo , Na Young Kim , and Ji Hyung Kim ,*
Mol. Cells 2021; 44(5): 310-317  https://doi.org/10.14348/molcells.2021.0059 PDF PubMed PubMed Central Google Scholar Search
Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation
Hyo Kyeong Kim , Mi Gyeong Jeong , and Eun Sook Hwang
Mol. Cells 2021; 44(5): 318-327  https://doi.org/10.14348/molcells.2021.0057 PDF PubMed PubMed Central Google Scholar Search
MHC multimer: A Molecular Toolbox for Immunologists
Jun Chang
Mol. Cells 2021; 44(5): 328-334  https://doi.org/10.14348/molcells.2021.0052 PDF PubMed PubMed Central Google Scholar Search
Regulatory Role of Zinc in Immune Cell Signaling
Bonah Kim and Won-Woo Lee
Mol. Cells 2021; 44(5): 335-341  https://doi.org/10.14348/molcells.2021.0061 PDF PubMed PubMed Central Google Scholar Search
MiT Family Transcriptional Factors in Immune Cell Functions
Seongryong Kim , Hyun-Sup Song , Jihyun Yu , and You-Me Kim
Mol. Cells 2021; 44(5): 342-355  https://doi.org/10.14348/molcells.2021.0067 PDF PubMed PubMed Central Supplementary File(s) Google Scholar Search
The Role of Gut Microbiota in Modulating Tumor Growth and Anticancer Agent Efficacy
Jaeho Kim and Heung Kyu Lee
Mol. Cells 2021; 44(5): 356-362  https://doi.org/10.14348/molcells.2021.0032 PDF PubMed PubMed Central Google Scholar Search
Clinical Perspectives to Overcome Acquired Resistance to Anti–Programmed Death-1 and Anti–Programmed Death Ligand-1 Therapy in Non-Small Cell Lung Cancer
Yong Jun Lee , Jii Bum Lee , Sang-Jun Ha , and Hye Ryun Kim
Mol. Cells 2021; 44(5): 363-373  https://doi.org/10.14348/molcells.2021.0044 PDF PubMed PubMed Central Google Scholar Search
  • e-Submission
  • For review & Editor

Current Issue

31 May 2021
Volume 44,
Number 5,
pp. 279~373
COVER PICTURE The immune system is an organic network of biological processes that protects the host from disease. Immune cells detect a wide variety of pathogens and responds with sophisticated mechanisms to maintain homeostasis. (Kim et al., pp. 301-309).
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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