• Research Article  31 August 2019

    Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway

    Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive. We demonstrate that PSPH promotes lung cancer progression through a noncanonical L-serine-independent pathway. PSPH was significantly associated with the prognosis of lung cancer patients and regulated the invasion and colony formation of lung canc ...

  • Research Article  31 August 2019

    Structural Study of Monomethyl Fumarate-Bound Human GAPDH

    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a core enzyme of the aerobic glycolytic pathway with versatile functions and is associated with cancer development. Recently, Kornberg et al. published the detailed correlation between GAPDH and di- or monomethyl fumarate (DMF or MMF), which are well-known GAPDH antagonists in the immune system. As an extension, herein, we report the crystal structure of MMF-bound human GAPDH at 2.29 Å. The MMF molecule is covalently linked to the catalytic ...

  • Research Article  31 August 2019

    Loss of ϐPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts

    βPix is a guanine nucleotide exchange factor for the Rho family small GTPases, Rac1 and Cdc42. It is known to regulate focal adhesion dynamics and cell migration. However, the in vivo role of βPix is currently not well understood. Here, we report the production and characterization of βPix-KO mice. Loss of βPix results in embryonic lethality accompanied by abnormal developmental features, such as incomplete neural tube closure, impaired axial rotation, and failure of allantoischorion ...

  • Research Article  31 August 2019

    NGSEA: Network-Based Gene Set Enrichment Analysis for Interpreting Gene Expression Phenotypes with Functional Gene Sets

    Gene set enrichment analysis (GSEA) is a popular tool to identify underlying biological processes in clinical samples using their gene expression phenotypes. GSEA measures the enrichment of annotated gene sets that represent biological processes for differentially expressed genes (DEGs) in clinical samples. GSEA may be suboptimal for functional gene sets; however, because DEGs from the expression dataset may not be functional genes per se but dysregulated genes perturbed by < ...


Mol. Cells 2019; 42(8): 569~616
Minireview
Transient Receptor Potential Channels and Metabolism
Subash Dhakal and Youngseok Lee
Mol. Cells 2019; 42(8): 569-578  https://doi.org/10.14348/molcells.2019.0007 PDF PubMed PubMed Central PubReader Google Scholar Search
Research Articles
NGSEA: Network-Based Gene Set Enrichment Analysis for Interpreting Gene Expression Phenotypes with Functional Gene Sets
Heonjong Han, Sangyoung Lee, and Insuk Lee
Mol. Cells 2019; 42(8): 579-588  https://doi.org/10.14348/molcells.2019.0065 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Loss of ϐPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts
TaeIn Kang, Seung Joon Lee, Younghee Kwon, and Dongeun Park
Mol. Cells 2019; 42(8): 589-596  https://doi.org/10.14348/molcells.2019.0140 PDF PubMed PubMed Central PubReader Google Scholar Search
Structural Study of Monomethyl Fumarate-Bound Human GAPDH
Jun Bae Park, Hayeong Park, Jimin Son, Sang-Jun Ha, and Hyun-Soo Cho
Mol. Cells 2019; 42(8): 597-603  https://doi.org/10.14348/molcells.2019.0114 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway
Seong-Min Park, Eun-Hye Seo, Dong-Hyuck Bae, Sung Soo Kim, Jina Kim, Weiwei Lin, Kyung-Hee Kim, Jong Bae Park, Yong Sung Kim, Jinlong Yin, and Seon-Young Kim
Mol. Cells 2019; 42(8): 604-616  https://doi.org/10.14348/molcells.2019.0160 PDF PubMed PubMed Central PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
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Current Issue

31 August 2019
Volume 42,
Number 8,
pp. 569~616
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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