• Minireview  31 December 2017

    Nuclear Bodies Built on Architectural Long Noncoding RNAs: Unifying Principles of Their Construction and Function

    Nuclear bodies are subnuclear, spheroidal, and membraneless compartments that concentrate specific proteins and/or RNAs. They serve as sites of biogenesis, storage, and sequestration of specific RNAs, proteins, or ribonucleoprotein complexes. Recent studies reveal that a subset of nuclear bodies in various eukaryotic organisms is constructed using architectural long noncoding RNAs (arcRNAs). Here, we describe the unifying mechanistic principles of the construction and function of these bodies ...

  • Article  31 December 2017

    Iron Homeostasis Controls Myeloid Blood Cell Differentiation in Drosophila

    Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood development, however, remain elusive. Here, we found that iron homeostasis is critical for differentiation of Drosophila blood cells in the larval hematopoietic organ, called the lymph gland. Supplementation of an iro ...

  • Minireview  31 December 2017

    Emerging Paradigm of Crosstalk between Autophagy and the Ubiquitin-Proteasome System

    Cellular protein homeostasis is maintained by two major degradation pathways, namely the ubiquitin-proteasome system (UPS) and autophagy. Until recently, the UPS and autophagy were considered to be largely independent systems targeting proteins for degradation in the proteasome and lysosome, respectively. However, the identification of crucial roles of molecular players such as ubiquitin and p62 in both of these pathways as well as the observation that blocking the UPS affects autophagy flux ...

  • Article  31 December 2017

    Odorant Receptors Containing Conserved Amino Acid Sequences in Transmembrane Domain 7 Display Distinct Expression Patterns in Mammalian Tissues

    Mammalian genomes are well established, and highly conserved regions within odorant receptors that are unique from other G-protein coupled receptors have been identified. Numerous functional studies have focused on specific conserved amino acids motifs; however, not all conserved motifs have been sufficiently characterized. Here, we identified a highly conserved 18 amino acid sequence motif within transmembrane domain seven (CAS-TM7) which was identified by aligning odorant receptor sequences ...

Mol. Cells 2018; 41(2): 73~159
Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells
Hirota Fujiki, Tatsuro Watanabe, Eisaburo Sueoka, Anchalee Rawangkan, and Masami Suganuma
Mol. Cells 2018; 41(2): 73-82  https://doi.org/10.14348/molcells.2018.2227 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
The Role of Hippo Pathway in Cancer Stem Cell Biology
Jae Hyung Park, Ji Eun Shin, and Hyun Woo Park
Mol. Cells 2018; 41(2): 83-92  https://doi.org/10.14348/molcells.2018.2242 PDF PubMed PubReader Google Scholar Search
MiR-199a/b-5p Inhibits Lymphangiogenesis by Targeting Discoidin Domain Receptor 1 in Corneal Injury
Sooeun Oh, Minkoo Seo, Jun-Sub Choi, Choun-Ki Joo, and Suk Kyeong Lee
Mol. Cells 2018; 41(2): 93-102  https://doi.org/10.14348/molcells.2018.2163 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
CBP7 Interferes with the Multicellular Development of Dictyostelium Cells by Inhibiting Chemoattractant-Mediated Cell Aggregation
Byeonggyu Park, Dong-Yeop Shin, and Taeck Joong Jeon
Mol. Cells 2018; 41(2): 103-109  https://doi.org/10.14348/molcells.2018.2170 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Generation of Isthmic Organizer-Like Cells from Human Embryonic Stem Cells
Junwon Lee, Sang-Hwi Choi, Dongjin R Lee, Dae-Sung Kim, and Dong-Wook Kim
Mol. Cells 2018; 41(2): 110-118  https://doi.org/10.14348/molcells.2018.2210 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Overexpression of microRNA-612 Restrains the Growth, Invasion, and Tumorigenesis of Melanoma Cells by Targeting Espin
Ying Zhu, Hao-liang Zhang, Qi-ying Wang, Min-jing Chen, and Lin-bo Liu
Mol. Cells 2018; 41(2): 119-126  https://doi.org/10.14348/molcells.2018.2235 PDF PubMed PubReader Google Scholar Search
Post-Translational Regulation of the RSF1 Chromatin Remodeler under DNA Damage
Sunwoo Min, Yong Won Choi, Hansol Yun, Sujin Jo, Jae-Hoon Ji, and Hyeseong Cho
Mol. Cells 2018; 41(2): 127-133  https://doi.org/10.14348/molcells.2018.2244 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Isolation and Functional Examination of the Long Non-Coding RNA Redrum
Yerim Lee, Charny Park, Sanghyuk Lee, Daekee Lee, and Jaesang Kim
Mol. Cells 2018; 41(2): 134-139  https://doi.org/10.14348/molcells.2018.2246 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
PPARα-Target Gene Expression Requires TIS21/BTG2 Gene in Liver of the C57BL/6 Mice under Fasting Condition
Allen Eugene Hong, Min Sook Ryu, Seung Jun Kim, Seung Yong Hwang, and In Kyoung Lim
Mol. Cells 2018; 41(2): 140-149  https://doi.org/10.14348/molcells.2018.2257 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Mass Spectrometry-Based Screening Platform Reveals Orco Interactome in Drosophila melanogaster
Kate E. Yu, Do-Hyoung Kim, Yong-In Kim, Walton D. Jones, and J. Eugene Lee
Mol. Cells 2018; 41(2): 150-159  https://doi.org/10.14348/molcells.2018.2305 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
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Current Issue

28 February 2018
Volume 41,
Number 2,
pp. 73~159
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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