• Research Article  30 April 2020

    Biological Functions and Identification of Novel Biomarker Expressed on the Surface of Breast Cancer-Derived Cancer Stem Cells via Proteomic Analysis

    Breast cancer is one of the most common life-threatening malignancies and the top cause of cancer deaths in women. Although many conventional therapies exist for its treatment, breast cancer still has many handicaps to overcome. Cancer stem cells (CSCs) are a well-known cause of tumor recurrences due to the ability of CSCs for self-renewal and differentiation into cell subpopulations, similar to stem cells. To fully treat breast cancer, a strategy for the treatment of both cancer cells and CSCs ...

  • Research Article  30 April 2020

    Structural Basis for the Antibiotic Resistance of Eukaryotic Isoleucyl-tRNA Synthetase

    Pathogenic aminoacyl-tRNA synthetases (ARSs) are attractive targets for anti-infective agents because their catalytic active sites are different from those of human ARSs. Mupirocin is a topical antibiotic that specifically inhibits bacterial isoleucy-ltRNA synthetase (IleRS), resulting in a block to protein synthesis. Previous studies on Thermus thermophilus IleRS indicated that mupirocin-resistance of eukaryotic IleRS is primarily due to differences in two amino acids, His581 and Leu583, ...

  • Rapid Report  30 April 2020

    Accelerated Evolution of the Regulatory Sequences of Brain Development in the Human Genome

    Genetic modifications in noncoding regulatory regions are likely critical to human evolution. Human-accelerated noncoding elements are highly conserved noncoding regions among vertebrates but have large differences across humans, which implies human-specific regulatory potential. In this study, we found that human-accelerated noncoding elements were frequently coupled with DNase I hypersensitive sites (DHSs), together with monomethylated and trimethylated histone H3 lysine 4, which are active re ...

  • Minireview  30 April 2020

    Zinc and Its Transporters in Epigenetics

    Epigenetic events like DNA methylation and histone modification can alter heritable phenotypes. Zinc is required for the activity of various epigenetic enzymes, such as DNA methyltransferases (DNMTs), histone acetyltransferases (HATs), histone deacetylases (HDACs), and histone demethylases, which possess several zinc binding sites. Thus, the dysregulation of zinc homeostasis can lead to epigenetic alterations. Zinc homeostasis is regulated by Zinc Transporters (ZnTs), Zrt- and Irt-like proteins ...

Mol. Cells 2020; 43(5): 419~499
Ceramide and Sphingosine 1-Phosphate in Liver Diseases
Woo-Jae Park , Jae-Hwi Song , Goon-Tae Kim , and Tae-Sik Park
Mol. Cells 2020; 43(5): 419-430  https://doi.org/10.14348/molcells.2020.0054 PDF PubMed Google Scholar Search
Cellular Contributors to Hypothalamic Inflammation in Obesity
Chan Hee Lee , Kyoungho Suk , Rina Yu , and Min-Seon Kim
Mol. Cells 2020; 43(5): 431-437  https://doi.org/10.14348/molcells.2020.0055 PDF PubMed Google Scholar Search
Research Articles
IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3
YingWei Chen , GuoDong Chang , XiaoJie Chen , YunPeng Li , HaiYu Li , Dong Cheng , Yi Tang , and HaiQiang Sang
Mol. Cells 2020; 43(5): 438-447  https://doi.org/10.14348/molcells.2019.2275 PDF PubMed Google Scholar Search
Gametophytic Abortion in Heterozygotes but Not in Homozygotes: Implied Chromosome Rearrangement during T-DNA Insertion at the ASF1 Locus in Arabidopsis
Yunsook Min , Jennifer M. Frost , and Yeonhee Choi
Mol. Cells 2020; 43(5): 448-458  https://doi.org/10.14348/molcells.2020.2290 PDF PubMed Supplementary File(s) Google Scholar Search
The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability
Yun Jeong Lee , Eun-Young Lee , Bo Hee Choi, Hyonchol Jang , Jae-Kyung Myung , and Hye Jin You
Mol. Cells 2020; 43(5): 459-468  https://doi.org/10.14348/molcells.2020.0041 PDF PubMed Google Scholar Search
Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation
Jae-Woong Choi , Jong-Wook Kim , Lap P. Nguyen , Huu C. Nguyen , Eun-Mee Park , Dong Hwa Choi , Kang Min Han , Sang Min Kang , Dongseob Tark , Yun-Sook Lim , and Soon B. Hwang
Mol. Cells 2020; 43(5): 469-478  https://doi.org/10.14348/molcells.2020.0018 PDF PubMed Google Scholar Search
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages
Sang Min Park , Van Anh Do-Thi , Jie-Oh Lee , Hayyoung Lee , and Young Sang Kim
Mol. Cells 2020; 43(5): 479-490  https://doi.org/10.14348/molcells.2020.0047 PDF PubMed Supplementary File(s) Google Scholar Search
WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice
Jaeoh Park , Jeong Sik Kim , Ji Hae Nahm , Sang-Kyum Kim , Da-Hye Lee , and Dae-Sik Lim
Mol. Cells 2020; 43(5): 491-499  https://doi.org/10.14348/molcells.2020.0093 PDF PubMed Supplementary File(s) Google Scholar Search
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Current Issue

31 May 2020
Volume 43,
Number 5,
pp. 419~499
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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