• Minireview  31 July 2018

    Structural Basis for LAR-RPTP–Mediated Synaptogenesis

    Leukocyte common antigen-related protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that regulate neurite outgrowth and neuronal regeneration. LAR-RPTPs have also received particular attention as the major presynaptic hubs for synapse organization through selective binding to numerous postsynaptic adhesion partners. Recent structural studies on LAR-RPTP–mediated trans-synaptic adhesion complexe ...

  • Article  31 July 2018

    Self-Reprogramming of Spermatogonial Stem Cells into Pluripotent Stem Cells without Microenvironment of Feeder Cells

    Spermatogonial stem cells (SSCs) derived from mouse testis are unipotent in regard of spermatogenesis. Our previous study demonstrated that SSCs can be fully reprogrammed into pluripotent stem cells, so called germline-derived pluripotent stem cells (gPS cells), on feeder cells (mouse embryonic fibroblasts), which supports SSC proliferation and induction of pluripotency. Because of an uncontrollable microenvironment caused by interactions with feeder cells, feeder-based SSC reprogramming is n ...

  • Article  31 July 2018

    Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members

    Upregulation of human telomerase reverse transcriptase (hTERT) expression is an important factor in the cellular survival and cancer. Although growing evidence suggests that hTERT inhibits cellular apoptosis by telomere-independent functions, the mechanisms involved are not fully understood. Here, we show that hTERT contains a BH3-like motif, a short peptide sequence found in BCL-2 family proteins, and interacts with anti-apoptotic BCL-2 family proteins MCL-1 and BCL-xL, suggesting a function ...

  • Minireview  31 July 2018

    Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells: Current Strategies and Limitations

    The capacity of differentiation of human pluripotent stem cells (hPSCs), which include both embryonic stem cells and induced pluripotent stem cells, into cardiomyocytes (CMs) in vitro provides an unlimited resource for human CMs for a wide range of applications such as cell based cardiac repair, cardiac drug toxicology screening, and human cardiac disease modeling. However, their applicability is significantly limited by immature phenotypes. It has been well known that curren ...

Mol. Cells 2018; 41(8): 705~807
Roles of Endoplasmic Reticulum Stress in Immune Responses
Jae-Seon So
Mol. Cells 2018; 41(8): 705-716  https://doi.org/10.14348/molcells.2018.0241 PDF PubMed PubReader Google Scholar Search
Unleashing the Therapeutic Potential of CAR-T Cell Therapy Using Gene-Editing Technologies
In-Young Jung, and Jungmin Lee
Mol. Cells 2018; 41(8): 717-723  https://doi.org/10.14348/molcells.2018.0242 PDF PubMed PubReader Google Scholar Search
Evidence for Volatile Memory in Plants: Boosting Defence Priming through the Recurrent Application of Plant Volatiles
Geun Cheol Song, and Choong-Min Ryu
Mol. Cells 2018; 41(8): 724-732  https://doi.org/10.14348/molcells.2018.0104 PDF PubMed PubReader Google Scholar Search
Integrative Profiling of Alternative Splicing Induced by U2AF1 S34F Mutation in Lung Adenocarcinoma Reveals a Mechanistic Link to Mitotic Stress
Suyeon Kim, Charny Park, Yukyung Jun, Sanghyuk Lee, Yeonjoo Jung, and Jaesang Kim
Mol. Cells 2018; 41(8): 733-741  https://doi.org/10.14348/molcells.2018.0176 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Abrogation of the Circadian Nuclear Receptor REV-ERBα Exacerbates 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration
Jeongah Kim, Sangwon Jang, Mijung Choi, Sooyoung Chung, Youngshik Choe, Han Kyoung Choe, Gi Hoon Son, Kunsoo Rhee, and Kyungjin Kim
Mol. Cells 2018; 41(8): 742-752  https://doi.org/10.14348/molcells.2018.0201 PDF PubMed PubReader Google Scholar Search
TRAF6 Distinctly Regulates Hematopoietic Stem and Progenitors at Different Periods of Development in Mice
Hyekang Kim, Seungwon Lee, and Seung-Woo Lee
Mol. Cells 2018; 41(8): 753-761  https://doi.org/10.14348/molcells.2018.0191 PDF PubMed PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
Globular Adiponectin Exerts a Pro-Inflammatory Effect via IκB/NF-κB Pathway Activation and Anti-Inflammatory Effect by IRAK-1 Downregulation
Kyoung-Hee Lee, Jiyeong Jeong, Jisu Woo, Chang-Hoon Lee, and Chul-Gyu Yoo
Mol. Cells 2018; 41(8): 762-770  https://doi.org/10.14348/molcells.2018.0005 PDF PubMed PubReader Google Scholar Search
Oleanolic Acids Inhibit Vascular Endothelial Growth Factor Receptor 2 Signaling in Endothelial Cells: Implication for Anti-Angiogenic Therapy
Da-Hye Lee, Jungsul Lee, Jongwook Jeon, Kyung-Jin Kim, Jang-Hyuk Yun, Han-Seok Jeong, Eun Hui Lee, Young Jun Koh, and Chung-Hyun Cho
Mol. Cells 2018; 41(8): 771-780  https://doi.org/10.14348/molcells.2018.0207 PDF PubMed PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
A WUSCHEL Homeobox Transcription Factor, OsWOX13, Enhances Drought Tolerance and Triggers Early Flowering in Rice
Pham-Thi Minh-Thu, Joung Sug Kim, Songhwa Chae, Kyong Mi Jun, Gang-Seob Lee, Dong-Eun Kim, Jong-Joo Cheong, Sang Ik Song, Baek Hie Nahm, and Yeon-Ki Kim
Mol. Cells 2018; 41(8): 781-798  https://doi.org/10.14348/molcells.2018.0203 PDF PubMed PubReader Supplementary File(s) Supplementary File(s) Google Scholar Search
A Novel Reciprocal Crosstalk between RNF168 and PARP1 to Regulate DNA Repair Processes
Jae Jin Kim, Seo Yun Lee, Soyeon Kim, Jee Min Chung, Mira Kwon, Jung Hyun Yoon, Sangwook Park, Yiseul Hwang, Dongsun Park, Jong-Soo Lee, and Ho Chul Kang
Mol. Cells 2018; 41(8): 799-807  https://doi.org/10.14348/molcells.2018.0078 PDF PubMed PubReader Google Scholar Search
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Current Issue

31 August 2018
Volume 41,
Number 8,
pp. 705~807
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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