• Minireview  31 December 2016

    Cancer Metabolism: Fueling More than Just Growth

    The early landmark discoveries in cancer metabolism research have uncovered metabolic processes that support rapid proliferation, such as aerobic glycolysis (Warburg effect), glutaminolysis, and increased nucleotide biosynthesis. However, there are limitations to the effectiveness of specifically targeting the metabolic processes which support rapid proliferation. First, as other normal proliferative tissues also share similar metabolic features, they may also be affected by such treatments. ...

  • Minireview  31 December 2016

    Imaging Single-mRNA Localization and Translation in Live Neurons

    Local protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA ...

  • Article  31 December 2016

    Baicalein Inhibits Epithelial to Mesenchymal Transition via Downregulation of Cyr61 and LOXL-2 in MDA-MB231 Breast Cancer Cells

    Epithelial-mesenchymal transition (EMT) is a critical step in the acquisition of the migratory and invasive capabilities associated with metastatic competence. Cysteine-rich protein 61 (CCN1/Cyr61) has been implicated as an important mediator in the proliferation and metastasis of breast cancer. Hence, Cyr61 and associated pathways are attractive targets for therapeutic interventions directed against the EMT. In the present study, we report that baicalein significantly inhibits the expression ...

  • Article  31 December 2016

    Tazarotene-Induced Gene 1 Enhanced Cervical Cell Autophagy through Transmembrane Protein 192

    Tazarotene-induced gene 1 (TIG1) is a retinoic acid-inducible protein that is considered a putative tumor suppressor. The expression of TIG1 is decreased in malignant prostate carcinoma or poorly differentiated colorectal adenocarcinoma, but TIG1 is present in benign or well-differentiated tumors. Ectopic TIG1 expression led to suppression of growth in cancer cells. However, the function of TIG1 in cell differentiation is still unknown. Using a yeast two-hybrid system, we found that transmemb ...

Mol. Cells 2017; 40(1): 1~81
SR Proteins: Binders, Regulators, and Connectors of RNA
Sunjoo Jeong
Mol. Cells 2017; 40(1): 1-9  https://doi.org/10.14348/molcells.2017.2319 PDF PubMed PubReader Google Scholar Search
Epigenetic Regulation of Axon Regeneration after Neural Injury
Jung Eun Shin, and Yongcheol Cho
Mol. Cells 2017; 40(1): 10-16  https://doi.org/10.14348/molcells.2017.2311 PDF PubMed PubReader Google Scholar Search
MAP Kinase-Mediated Negative Regulation of Symbiotic Nodule Formation in Medicago truncatula
Hojin Ryu, Carole Laffont, Florian Frugier, and Ildoo Hwang
Mol. Cells 2017; 40(1): 17-23  https://doi.org/10.14348/molcells.2017.2211 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex
Inkyu Hwang, Kwangmi Kim, Sojin Choi, and Maria Lomunova
Mol. Cells 2017; 40(1): 24-36  https://doi.org/10.14348/molcells.2017.2218 PDF PubMed PubReader Google Scholar Search
PKCθ-Mediated PDK1 Phosphorylation Enhances T Cell Activation by Increasing PDK1 Stability
Jung-Ah Kang, Hyunwoo Choi, Taewoo Yang, Steve K. Cho, Zee-Yong Park, and Sung-Gyoo Park
Mol. Cells 2017; 40(1): 37-44  https://doi.org/10.14348/molcells.2017.2236 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Concurrent Hypermethylation of SFRP2 and DKK2 Activates the Wnt/β-Catenin Pathway and Is Associated with Poor Prognosis in Patients with Gastric Cancer
Hao Wang, Xiang-Long Duan, Xiao-Li Qi, Lei Meng, Yi-Song Xu, Tong Wu, and Peng-Gao Dai
Mol. Cells 2017; 40(1): 45-53  https://doi.org/10.14348/molcells.2017.2245 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy
Hyuna Kim, Youngmi Kim, and Dooil Jeoung
Mol. Cells 2017; 40(1): 54-65  https://doi.org/10.14348/molcells.2017.2258 PDF PubMed PubReader Google Scholar Search
Salubrinal Alleviates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Endoplasmic Reticulum Stress Pathway
Shilpa Rani, Pradeep Kumar Sreenivasaiah, Chunghee Cho, and Do Han Kim
Mol. Cells 2017; 40(1): 66-72  https://doi.org/10.14348/molcells.2017.2259 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
Development of a Reporter System for In Vivo Monitoring of γ-Secretase Activity in Drosophila
Young Gi Hong, Seyun Roh, Donggi Paik, and Sangyun Jeong
Mol. Cells 2017; 40(1): 73-81  https://doi.org/10.14348/molcells.2017.2294 PDF PubMed PubReader Supplementary File(s) Google Scholar Search
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Current Issue

31 January 2017
Volume 40,
Number 1,
pp. 1~81
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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