• Research Article  30 November 2020

    Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation

    Recent studies have highlighted that early enhancement of the glycolytic pathway is a mode of maintaining the pro-inflammatory status of immune cells. Thiamine, a well-known co-activator of pyruvate dehydrogenase complex, a gatekeeping enzyme, shifts energy utilization of glucose from glycolysis to oxidative phosphorylation. Thus, we hypothesized that thiamine may modulate inflammation by alleviating metabolic shifts during immune cell activation. First, using allithiamine, which showed the most ...

  • Research Article  30 November 2020

    Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2

    Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious disease with multiple severe symptoms, such as fever over 37.5°C, cough, dyspnea, and pneumonia. In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. Five miRNAs (hsa-miR-15a-5p, hsa-miR ...

  • Research Article  30 November 2020

    HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells

    Hypoxia induces the expression of several genes through the activation of a master transcription factor, hypoxia-inducible factor (HIF)-1α. This study shows that hypoxia strongly induced the expression of two carboxypeptidases (CP), CPA4 and CPE, in an HIF-1α-dependent manner. The hypoxic induction of CPA4 and CPE gene was accompanied by the recruitment of HIF-1α and upregulation in the active histone modification, H3K4me3, at their promoter regions. The hypoxic responsiveness o ...

  • Research Article  30 November 2020

    Establishment of a NanoBiT-Based Cytosolic Ca2+ Sensor by Optimizing Calmodulin-Binding Motif and Protein Expression Levels

    Cytosolic Ca2+ levels ([Ca2+]c) change dynamically in response to inducers, repressors, and physiological conditions, and aberrant [Ca2+]c concentration regulation is associated with cancer, heart failure, and diabetes. Therefore, [Ca2+]c is considered as a good indicator of physiological and pathological cellular responses, and is a crucial biomarker for drug discovery. A genetically encoded calcium indicator (GECI) wa ...

  • Minireview  30 November 2020

    Mechanisms of Macromolecular Interactions Mediated by Protein Intrinsic Disorder

    Intrinsically disordered proteins or regions (IDPs or IDRs) are widespread in the eukaryotic proteome. Although lacking stable three-dimensional structures in the free forms, IDRs perform critical functions in various cellular processes. Accordingly, mutations and altered expression of IDRs are associated with many pathological conditions. Hence, it is of great importance to understand at the molecular level how IDRs interact with their binding partners. In particular, discovering the unique int ...


Mol. Cells 2020; 43(11): 899~973
Minireview
Mechanisms of Macromolecular Interactions Mediated by Protein Intrinsic Disorder
Sunghyun Hong , Sangmin Choi , Ryeonghyeon Kim , and Junseock Koh
Mol. Cells 2020; 43(11): 899-908  https://doi.org/10.14348/molcells.2020.0186 PDF PubMed Google Scholar Search
Research Articles
Establishment of a NanoBiT-Based Cytosolic Ca2+ Sensor by Optimizing Calmodulin-Binding Motif and Protein Expression Levels
Lan Phuong Nguyen , Huong Thi Nguyen , Hyo Jeong Yong , Arfaxad Reyes-Alcaraz , Yoo-Na Lee , Hee-Kyung Park , Yun Hee Na , Cheol Soon Lee , Byung-Joo Ham , Jae Young Seong , and Jong-Ik Hwang
Mol. Cells 2020; 43(11): 909-920  https://doi.org/10.14348/molcells.2020.0144 PDF PubMed Supplementary File(s) Google Scholar Search
The Transmembrane Adaptor Protein LIME Is Essential for Chemokine-Mediated Migration of Effector T Cells to Inflammatiory Sites
Inyoung Park , Myongsun Son , Eunseon Ahn , Young-Woong Kim, Young-Yun Kong , and Yungdae Yun
Mol. Cells 2020; 43(11): 921-934  https://doi.org/10.14348/molcells.2020.0124 PDF PubMed Supplementary File(s) Google Scholar Search
Aryl Sulfonamides Induce Degradation of Aryl Hydrocarbon Receptor Nuclear Translocator through CRL4DCAF15 E3 Ligase
Sung Ah Kim , Seung-Hyun Jo , Jin Hwa Cho , Min Yeong Yu , Ho-Chul Shin , Jung-Ae Kim , Sung Goo Park , Byoung Chul Park , Sunhong Kim , and Jeong-Hoon Kim
Mol. Cells 2020; 43(11): 935-944  https://doi.org/10.14348/molcells.2020.0122 PDF PubMed Supplementary File(s) Google Scholar Search
HIF-1α-Dependent Induction of Carboxypeptidase A4 and Carboxypeptidase E in Hypoxic Human Adipose-Derived Stem Cells
Yunwon Moon , Ramhee Moon , Hyunsoo Roh , Soojeong Chang , Seongyeol Lee , and Hyunsung Park
Mol. Cells 2020; 43(11): 945-952  https://doi.org/10.14348/molcells.2020.0100 PDF PubMed Google Scholar Search
Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2
Woo Ryung Kim , Eun Gyung Park , Kyung-Won Kang , Sang-Myeong Lee , Bumseok Kim , and Heui-Soo Kim
Mol. Cells 2020; 43(11): 953-963  https://doi.org/10.14348/molcells.2020.0177 PDF PubMed Google Scholar Search
Allithiamine Exerts Therapeutic Effects on Sepsis by Modulating Metabolic Flux during Dendritic Cell Activation
Eun Jung Choi , Chang Hyun Jeon , Dong Ho Park , and Tae-Hwan Kwon
Mol. Cells 2020; 43(11): 964-973  https://doi.org/10.14348/molcells.2020.0198 PDF PubMed Supplementary File(s) Google Scholar Search
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Current Issue

30 November 2020
Volume 43,
Number 11,
pp. 899~973
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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