• Minireview  31 October 2018

    PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins

    Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pa ...

  • Article  31 October 2018

    Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis

    Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In thi ...

  • Article  31 October 2018

    Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells

    In pancreatic β cells, glucose stimulates the biosynthesis of insulin at transcriptional and post-transcriptional levels. The RNA-binding protein, polypyrimidine tract-binding protein 1 (PTBP1), also named hnRNP I, acts as a critical mediator of insulin biosynthesis through binding to the pyrimidine-rich region in the 3’-untranslated region (UTR) of insulin mRNA. However, the underlying mechanism that regulates its expression in β cells is unclear. Here, we report that glucose induces the ...

  • Minireview  31 October 2018

    Brain Somatic Mutations in Epileptic Disorders

    During the cortical development, cells in the brain acquire somatic mutations that can be implicated in various neurodevelopmental disorders. There is increasing evidence that brain somatic mutations lead to sporadic form of epileptic disorders with previously unknown etiology. In particular, malformation of cortical developments (MCD), ganglioglioma (GG) associated with intractable epilepsy and non-lesional focal epilepsy (NLFE) are known to be attributable to brain somatic mutations in mTOR ...


Mol. Cells 2018; 41(11): 933~992
Minireviews
Chemically Induced Cellular Proteolysis: An Emerging Therapeutic Strategy for Undruggable Targets
Seonghyeon Moon, and Byung-Hoon Lee
Mol. Cells 2018; 41(11): 933-942  https://doi.org/10.14348/molcells.2018.0372 PDF PubReader Google Scholar Search
CRISPR and Target-Specific DNA Endonucleases for Efficient DNA Knock-in in Eukaryotic Genomes
Seung Hwan Lee, Sunghyun Kim, and Junho K Hur
Mol. Cells 2018; 41(11): 943-952  https://doi.org/10.14348/molcells.2018.0408 PDF PubReader Google Scholar Search
Articles
Dynamic Transcriptome, DNA Methylome, and DNA Hydroxymethylome Networks During T-Cell Lineage Commitment
Byoung-Ha Yoon, Mirang Kim, Min-Hyeok Kim, Hee-Jin Kim, Jeong-Hwan Kim, Jong Hwan Kim, Jina Kim, Yong Sung Kim, Daeyoup Lee, Suk-Jo Kang, and Seon-Young Kim
Mol. Cells 2018; 41(11): 953-963  https://doi.org/10.14348/molcells.2018.0213 PDF PubReader Supplementary File(s) Google Scholar Search
Laminar Flow Inhibits ER Stress-Induced Endothelial Apoptosis through PI3K/Akt-Dependent Signaling Pathway
Suji Kim, and Chang-Hoon Woo
Mol. Cells 2018; 41(11): 964-970  https://doi.org/10.14348/molcells.2018.0111 PDF PubReader Google Scholar Search
Inhibition of MicroRNA-221 and 222 Enhances Hematopoietic Differentiation from Human Pluripotent Stem Cells via c-KIT Upregulation
Ji Yoon Lee, MyungJoo Kim, Hye-Ryeon Heo, Kwon-Soo Ha, Eun-Taek Han, Won Sun Park, Se-Ran Yang, and Seok-Ho Hong
Mol. Cells 2018; 41(11): 971-978  https://doi.org/10.14348/molcells.2018.0244 PDF PubReader Google Scholar Search
Transcriptome Profiling and Characterization of Drought-Tolerant Potato Plant (Solanum tuberosum L.)
Ki-Beom Moon, Dong-Joo Ahn, Ji-Sun Park, Won Yong Jung, Hye Sun Cho, Hye-Ran Kim, Jae-Heung Jeon, Youn-il Park, and Hyun-Soon Kim
Mol. Cells 2018; 41(11): 979-992  https://doi.org/10.14348/molcells.2018.0312 PDF PubReader Supplementary File(s) Google Scholar Search
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Current Issue

30 November 2018
Volume 41,
Number 11,
pp. 933~992
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*


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