• Minireview  31 March 2018

    New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O

    Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be inv ...

  • Article  31 March 2018

    Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine

    Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonst ...

  • Minireview  31 March 2018

    Evolution and Design Principles of the Diverse Chloroplast Transit Peptides

    Chloroplasts are present in organisms belonging to the kingdom Plantae. These organelles are thought to have originated from photosynthetic cyanobacteria through endosymbiosis. During endosymbiosis, most cyanobacterial genes were transferred to the host nucleus. Therefore, most chloroplast proteins became encoded in the nuclear genome and must return to the chloroplast after translation. The N-terminal cleavable transit peptide (TP) is necessary and sufficient for the import of nucleus-encode ...

  • Article  31 March 2018

    Increased Primary Cilia in Idiopathic Pulmonary Fibrosis

    Primary cilia are solitary, non-motile, axonemal microtubule-based antenna-like organelles that project from the plasma membrane of most mammalian cells and are implicated in transducing hedgehog signals during development. It was recently proposed that aberrant SHH signaling may be implicated in the progression of idiopathic pulmonary fibrosis (IPF). However, the distribution and role of primary cilia in IPF remains unclear. Here, we clearly observed the primary cilia in alveolar epithelial ...

Mol. Cells 2018; 41(4): 257~372
Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye
Kyeong Hwan Moon, and Jin Woo Kim
Mol. Cells 2018; 41(4): 257-263  https://doi.org/10.14348/molcells.2018.0091 PDF PubMed PubMed Central PubReader Google Scholar Search
Cooperative Instruction of Signaling and Metabolic Pathways on the Epigenetic Landscape
Jung-Ae Kim
Mol. Cells 2018; 41(4): 264-270  https://doi.org/10.14348/molcells.2018.0076 PDF PubMed PubMed Central PubReader Google Scholar Search
IFIT1 Expression Patterns Induced by H9N2 Virus and Inactivated Viral Particle in Human Umbilical Vein Endothelial Cells and Bronchus Epithelial Cells
Bo Feng, Qian Zhang, Jianfang Wang, Hong Dong, Xiang Mu, Ge Hu, and Tao Zhang
Mol. Cells 2018; 41(4): 271-281  https://doi.org/10.14348/molcells.2018.2091 PDF PubMed PubMed Central PubReader Google Scholar Search
Cigarette Smoke Extract Enhances IL-17A-Induced IL-8 Production via Up-Regulation of IL-17R in Human Bronchial Epithelial Cells
Kyoung-Hee Lee, Chang-Hoon Lee, Jisu Woo, Jiyeong Jeong, An-Hee Jang, and Chul-Gyu Yoo
Mol. Cells 2018; 41(4): 282-289  https://doi.org/10.14348/molcells.2018.2123 PDF PubMed PubMed Central PubReader Google Scholar Search
Indole-3-Carbinol Promotes Goblet-Cell Differentiation Regulating Wnt and Notch Signaling Pathways AhR-Dependently
Joo-Hung Park, Jeong-Min Lee, Eun-Jin Lee, Won-Bhin Hwang, and Da-Jeong Kim
Mol. Cells 2018; 41(4): 290-300  https://doi.org/10.14348/molcells.2018.2167 PDF PubMed PubMed Central PubReader Google Scholar Search
A Novel Tetrameric Assembly Configuration in VV2_1132, a LysR-Type Transcriptional Regulator in Vibrio vulnificus
Yongdae Jang, Garam Choi, Seokho Hong, Inseong Jo, Jinsook Ahn, Sang Ho Choi, and Nam-Chul Ha
Mol. Cells 2018; 41(4): 301-310  https://doi.org/10.14348/molcells.2018.2190 PDF PubMed PubMed Central PubReader Google Scholar Search
Regulation of Ethylene Biosynthesis by Phytohormones in Etiolated Rice (Oryza sativa L.) Seedlings
Han Yong Lee, and Gyeong Mee Yoon
Mol. Cells 2018; 41(4): 311-319  https://doi.org/10.14348/molcells.2018.2224 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
δ-Catenin Increases the Stability of EGFR by Decreasing c-Cbl Interaction and Enhances EGFR/Erk1/2 Signaling in Prostate Cancer
Nensi Shrestha, Hridaya Shrestha, Taeyong Ryu, Hangun Kim, Shishli Simkhada, Young-Chang Cho, So-Yeon Park, Sayeon Cho, Kwang-Youl Lee, Jae-Hyuk Lee, and Kwonseop Kim
Mol. Cells 2018; 41(4): 320-330  https://doi.org/10.14348/molcells.2018.2292 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Structural Basis for Recognition of L-lysine, L-ornithine, and L-2,4-diamino Butyric Acid by Lysine Cyclodeaminase
Kyungjin Min, Hye-Jin Yoon, Atsushi Matsuura, Yong Hwan Kim, and Hyung Ho Lee
Mol. Cells 2018; 41(4): 331-341  https://doi.org/10.14348/molcells.2018.2313 PDF PubMed PubMed Central PubReader Google Scholar Search
Identification of the Regulatory Region Responsible for Vascular Tissue–Specific Expression in the Rice Hd3a Promoter
Richa Pasriga, Lae-Hyeon Cho, Jinmi Yoon, and Gynheung An
Mol. Cells 2018; 41(4): 342-350  https://doi.org/10.14348/molcells.2018.2320 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
AtMyb56 Regulates Anthocyanin Levels via the Modulation of AtGPT2 Expression in Response to Sucrose in Arabidopsis
Chan Young Jeong, Jun Hyeok Kim, Won Je Lee, Joo Yeon Jin, Jongyun Kim, Suk-Whan Hong, and Hojoung Lee
Mol. Cells 2018; 41(4): 351-361  https://doi.org/10.14348/molcells.2018.2195 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence
Hyun-Kyung Kim, Mi Ae Kang, Mi-Sook Kim, Young-Joo Shin, Sung-Gil Chi, and Jae-Hoon Jeong
Mol. Cells 2018; 41(4): 362-372  https://doi.org/10.14348/molcells.2018.2291 PDF PubMed PubMed Central PubReader Supplementary File(s) Google Scholar Search
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Current Issue

30 April 2018
Volume 41,
Number 4,
pp. 257~372
dRAGging Amino Acid-mTORC1 Signaling by SH3BP4
Young-Mi Kim, and Do-Hyung Kim*
Received September 19, 2012; Accepted December 4, 2012.
Olfactory Carbon Dioxide Detection by Insects and Other Animals
Walton Jones
Received January 30, 2013; Accepted February 2, 2013.
Broad Activity against Porcine Bacterial Pathogens Displayed by Two Insect Antimicrobial Peptides Moricin and Cecropin B
Han Hu, Chunmei Wang, Xiaozhen Guo, Wentao Li, Yang Wang, and Qigai He
Received May 4, 2012; Accepted November 20, 2012.
A MAP Kinase Pathway Is Implicated in the Pseudohyphal Induction by Hydrogen Peroxide in Candica albicans
Kavitha Srinivasa, Jihyun Kim, Subog Yee, Wankee Kim*, and Wonja Choi*
Activation of Rice nicotianamine synthase 2 (OsNAS2) Enhances Iron Availability for Biofortification
Sichul Lee, You-Sun Kim, Un Sil Jeon, Yoon-Keun Kim, Jan K. Schjoerring, and Gynheung An*
Rhythmic Oscillation of Histone Acetylation and Methylation at the Arabidopsis Central Clock Loci
Hae-Ryong Song, and Yoo-Sun Noh*

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