An Impaired Inflammatory and Innate Immune Response in COVID-19
Sung Ho Park *
Department of Biological Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea
Received March 22, 2021; Revised May 4, 2021; Accepted May 5, 2021.; Published online June 7, 2021.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people around the world and caused a global pandemic of coronavirus disease 2019 (COVID-19). It has been suggested that uncontrolled, exaggerated inflammation contributes to the adverse outcomes of COVID-19. In this review, we summarize our current understanding of the innate immune response elicited by SARS-CoV-2 infection and the hyperinflammation that contributes to disease severity and death. We also discuss the immunological determinants behind COVID-19 severity and propose a rationale for the underlying mechanisms.
Keywords: COVID-19, cytokine storm, inflammatory cytokines, immunoparalysis, innate immune response


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31 May 2021 Volume 44,
Number 5, pp. 279~373
COVER PICTURE The immune system is an organic network of biological processes that protects the host from disease. Immune cells detect a wide variety of pathogens and responds with sophisticated mechanisms to maintain homeostasis. (Kim et al., pp. 301-309).

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