Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer Associated Adipocytes
Yae Chan Song 1,3, Seung Eon Lee 1,3, Young Jin 2, Hyun Woo Park 1,*, Kyung-Hee Chun 2,*, and Han-Woong Lee 1,*
1Department of Biochemistry, College of Life Science and Biotechnology and Yonsei Laboratory Animal Research Center, Yonsei University, Seoul 03722, Korea, 2Department of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul 03722, Korea, 3These authors contributed equally to this work.
Received May 11, 2020; Revised June 16, 2020; Accepted June 26, 2020.; Published online August 5, 2020.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
Recently, tumor microenvironment (TME) and its stromal constituents have provided profound insights into understanding alterations in tumor behavior. After each identification regarding the unique roles of TME compartments, non-malignant stromal cells are found to provide a sufficient tumorigenic niche for cancer cells. Of these TME constituents, adipocytes represent a dynamic population mediating endocrine effects to facilitate the crosstalk between cancer cells and distant organs, as well as the interplay with nearby tumor cells. To date, the prevalence of obesity has emphasized the significance of metabolic homeostasis along with adipose tissue (AT) inflammation, cancer incidence, and multiple pathological disorders. In this review, we summarized distinct characteristics of hypertrophic adipocytes and cancer to highlight the importance of an individual's metabolic health during cancer therapy. As AT undergoes inflammatory alterations inducing tissue remodeling, immune cell infiltration, and vascularization, these features directly influence the TME by favoring tumor progression. A comparison between inflammatory AT and progressing cancer could potentially provide crucial insights into delineating the complex communication network between uncontrolled hyperplastic tumors and their microenvironmental components. In turn, the comparison will unravel the underlying properties of dynamic tumor behavior, advocating possible therapeutic targets within TME constituents.
Keywords: adipose tissue, cancer-associated adipocyte, inflammation, obesity, tumor microenvironment


Current Issue

31 August 2020 Volume 43,
Number 8, pp. 671~762

This Article


Cited By Articles
  • CrossRef (0)

Social Network Service
Services

Indexed in

  • Science Central
  • CrossMark