Mol. Cells 2018; 41(6): 495~505
Current Challenges of Streptococcus Infection and Effective Molecular, Cellular, and Environmental Control Methods in Aquaculture
Anshuman Mishra1, Gyu-Hwi Nam1,2, Jeong-An Gim1,2,3, Hee-Eun Lee1,2, Ara Jo1,2, and Heui-Soo Kim1,2,*
1Institute of Systems Biology, Pusan National University, Busan 46241, Korea, 2Department of Biological Sciences, College of
Natural Sciences, Pusan National University, Busan 46241, Korea, 3The Genomics Institute, Life Sciences Department, UNIST,
Ulsan 44919, Korea
Received August 2, 2017; Revised March 15, 2018; Accepted April 4, 2018.; Published online May 10, 2018.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

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Several bacterial etiological agents of streptococcal disease have been associated with fish mortality and serious global economic loss. Bacterial identification based on biochemical, molecular, and phenotypic methods has been routinely used, along with assessment of morphological analyses. Among these, the molecular method of 16S rRNA sequencing is reliable, but presently, advanced genomics are preferred over other traditional identification methodologies. This review highlights the geographical variation in strains, their relatedness, as well as the complexity of diagnosis, pathogenesis, and various control methods of streptococcal infections. Several limitations, from diagnosis to control, have been reported, which makes prevention and containment of streptococcal disease difficult. In this review, we discuss the challenges in diagnosis, pathogenesis, and control methods and suggest appropriate molecular (comparative genomics), cellular, and environmental solutions from among the best available possibilities.
Keywords: antimicrobial, aquaculture, geography, sequencing,

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30 June 2018 Volume 41,
Number 6, pp. 495~611

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