Post-Translational Regulations of Transcriptional Activity of RUNX2
Hyun-Jung Kim, Woo-Jin Kim, and Hyun-Mo Ryoo*
Department of Molecular Genetics & Dental Pharmacology, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 08826, Korea
Received October 29, 2019; Accepted December 4, 2019.; Published online December 27, 2019.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

ABSTRACT
Runt-related transcription factor 2 (RUNX2) is a key transcription factor for bone formation and osteoblast differentiation. Various signaling pathways and mechanisms that regulate the expression and transcriptional activity of RUNX2 have been thoroughly investigated since the involvement of RUNX2 was first reported in bone formation. As the regulation of Runx2 expression by extracellular signals has recently been reviewed, this review focuses on the regulation of post-translational RUNX2 activity. Transcriptional activity of RUNX2 is regulated at the post-translational level by various enzymes including kinases, acetyl transferases, deacetylases, ubiquitin E3 ligases, and prolyl isomerases. We describe a sequential and linear causality between posttranslational modifications of RUNX2 by these enzymes. RUNX2 is one of the most important osteogenic transcription factors; however, it is not a suitable drug target. Here, we suggest enzymes that directly regulate the stability and/or transcriptional activity of RUNX2 at a post-translational level as effective drug targets for treating bone diseases.
Keywords: osteoblast differentiation, phosphorylationdirected Isomerization, post-translational modification, RUNX2, transcriptional activity


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31 January 2020 Volume 43,
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