AtMyb56 Regulates Anthocyanin Levels via the Modulation of AtGPT2 Expression in Response to Sucrose in Arabidopsis 
Chan Young Jeong1,2, Jun Hyeok Kim3, Won Je Lee1, Joo Yeon Jin1, Jongyun Kim1, Suk-Whan Hong4,*, and Hojoung Lee1,2,*
1Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02473, Korea, 2Institute of Life Science and Natural Resources, Korea University, Seoul 02473, Korea, 3Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom, 4Department of Molecular Biotechnology, College of Agriculture and Life Sciences, Bioenergy Research Institute, Chonnam National University, Gwangju 61186, Korea
*Correspondence: (HL); (SWH) 
Received September 7, 2017; Revised December 29, 2017; Accepted January 22, 2018.; Published online February 28, 2018.
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Sucrose is a crucial compound for the growth and development of plants, and the regulation of multiple genes depends on the amount of soluble sugars present. Sucrose acts as a signaling molecule that regulates a proton-sucrose symporter, with its sensor being the sucrose transporter. Flavonoid and anthocyanin biosynthesis are regulated by sucrose, and sucrose signaling can affect flavonoid and anthocyanin accumulation. In the present study, we found a Myb transcription factor affecting accumulation of anthocyanin. AtMyb56 showed an increase in its expression in response to sucrose treatment. Under normal conditions, anthocyanin accumulation was similar between Col-0 (wild type) and atmyb56 mutant seedlings; however, under sucrose treatment, the level of anthocyanin accumulation was lower in the atmyb56 mutant plants than in Col-0 plants. Preliminary microarray analysis led to the investigation of the expression of one candidate gene, AtGPT2 , in the atmyb56 mutant. The phosphate translocator, which is a plastidial phosphate antiporter family, catalyzes the import of glucose-6-phosphate (G-6-P) into the chloroplast. AtGPT2 gene expression was altered in atmyb56 seedlings in a sucrose dependent manner in response to circadian cycle. Furthermore, the lack of AtMyb56 resulted in altered accumulation of maltose in a sucrose dependent manner. Therefore, the sucrose responsive AtMyb56 regulates AtGPT2 gene expression in a sucrose-dependent manner to modulate maltose and anthocyanin accumulations in response to the circadian cycle.
Keywords: Anthocyanin, Arabidopsis thaliana, AtMyb56, Myb transcription factor, plastidial glucose-6-phosphate/phosphate translocator, sucrose

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28 February 2018 Volume 41,
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