Mol. Cells 2018; 41(3): 256  https://doi.org/10.14348/molcells.2018.0091
Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye
Kyeong Hwan Moon, and Jin Woo Kim*
Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea
*Correspondence: jinwookim@kaist.ac.kr
Received March 2, 2018; Revised March 21, 2018; Accepted March 22, 2018.; Published online April 11, 2018.
© Korean Society for Molecular and Cellular Biology. All rights reserved.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit (http://creativecommons.org/licenses/by-nc-sa/3.0/).
ABSTRACT
Vertebrate organ development is accompanied by demarcation of tissue compartments, which grow coordinately with their neighbors. Hence, perturbing the coordinative growth of neighboring tissue compartments frequently results in organ malformation. The growth of tissue compartments is regulated by multiple intercellular and intracellular signaling pathways, including the Hippo signaling pathway that limits the growth of various organs. In the optic neuroepithelial continuum, which is partitioned into the retina, retinal pigment epithelium (RPE) and ciliary margin (CM) during eye development, the Hippo signaling activity operates differentially, as it does in many tissues. In this review, we summarize recent studies that have explored the relationship between the Hippo signaling pathway and growth of optic neuroepithelial compartments. We will focus particularly on the roles of a tumor suppressor, neurofibromin 2 (NF2), whose expression is not only dependent on compartment-specific transcription factors, but is also subject to regulation by a Hippo-Yap feedback signaling circuit.
Keywords: ciliary margin, eye development, Hippo pathway, neurofibromin 2 (NF2), retina

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31 March 2018 Volume 41,
Number 3, pp. 161~255

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