Molecules and Cells

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Fig. 2.

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Fig. 2. IFN priming activates macrophages and reverses the state of tolerance. TLR agonists and TNF induce a state of tolerance in which chromatin is closed, that is associated with immunoparalysis. IFN priming of basal or tolerized macrophages strongly increases responsiveness and pro-inflammatory responses by priming and opening the chromatin at the non-ISGs locus.
Mol. Cells 2021;44:384~391
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