Molecules and Cells

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Fig. 2.

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Fig. 2. Genome annotation, polyprotein processing, stepwise replication, and host immune evasion mechanism of SARS-CoV-2. (A) The ORF1a and ORF1b are transcribed into pp1a and pp1ab; the latter is transcribed as the result of –1 ribosomal frameshift at the overlapping point between IRF1a and ORF1b. Nsp3 (PLpro) cleaves pp1a at three points (red arrows), and Nsp5 (3CLpro) releases nsp4–nsp16 by cleaving pp1a and pp1ab (green arrows). (B) Following membrane fusion, the viral RTC members generated by pp1a and pp1ab are involved in the biogenesis of ROs (left). The SARS-CoV-2 proteins antagonizes IFNs (red lines) (right). ORF, open reading frames; S, spike; E, envelope; M, membrane; N, nucleocapsid; ssRNA, single strand RNA; sgRNA, subgenomic RNA; gRNA, genomic RNA; dsRNA, double strand RNA.
Mol. Cells 2021;44:408~421
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