Molecules and Cells

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Fig. 8.

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Fig. 8. A schematic of the NSM00158 mechanism preventing nonunion occurrence. The small-molecule compound NSM00158 specifically inhibited CtBP2 function and caused the disassociation of CtBP2 from the CtBP2-p300-Runx2 complex. The released p300-Runx2 complex binds to the promoters of bone development and differentiation genes, including OSC, ALPL, COLA1, IBSP, SPP1, and MMP13, to activate their expression. The induction of these genes prevented the occurrence of nonunion.
Mol. Cells 2020;43:517~529
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