Molecules and Cells

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Fig. 3.

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Fig. 3. (A) A schematic showing large scale deletion (red dotted lines) changing the distance between two genomic regions A and B from d1 to d2 (left). WGS read coverage in original and deletion-harboring genome and the resulting plot of read coverage against genomic distance (top). A schematic showing regions A (red line) and B (blue line) in 3D genome space for original and deletion-harboring chromatin and the resulting plot of ligation frequency against genomic distance (bottom). (B–E) Categorization of expected gradient patterns in chromatin contact maps (top), normal TAD structure (middle), and the changes in TAD structure (bottom) for deletion (B), inversion (C), translocation (D), and duplications (E).
Mol. Cells 2019;42:512~522
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