Molecules and Cells

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Fig. 2.

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Fig. 2. DEGs were isolated separately for AC and SC, as displayed. Left panels (A and D) show the results of the heatmap analysis accompanied by the unsupervised clustering of samples using the 150 AC-DEGs and 58 SC-DEGs. Dendrograms showing distances between the samples, generally displayed at the top of heatmaps, are omitted, and colored bars are used instead to represent normal samples (colored cyan blue) and COPD samples (colored red). The middle panels (B and E) show the results of the PCA accompanied by k-means clustering (k = 3). Each dot represents one patient sample; normal, intermediate, and COPD samples are colored cyan, gray, and red, respectively. Some outlier samples that were clinically diagnosed as normal but showed similar gene expression to COPD, or vice versa, as indicated with colored cyan blue and red circles, respectively. These outliers were excluded from further analyses. The right panels (C and F) show boxplots of the FEV1/FVC ratios for N, I and C samples. The red dotted lines represent the median value of N. Significance was tested using Student’s t -test (*p < 0.05; **p < 0.01; ***p < 0.001).
Mol. Cells 2019;42:333~344
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