Molecules and Cells

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Fig. 1.

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Fig. 1. Metformin inhibits mitochondrial complex I and activates AMPK via decreasing ATP levels, thereby increasing glycolysis and lipolysis and inhibiting gluconeogenesis and lipogenesis. Metformin also increases glucose translocation and improves insulin sensitivity. See the text for more details.
Mol. Cells 2019;42:292~300
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