Molecules and Cells

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Fig. 4.

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Fig. 4. (A) Expression of specific DEGs at each stage and correlation between 5mC and 5hmC. The methylation level in the promoter region of stage-specific up-regulated genes was lower at the CD4 stage than that at the other stages, whereas the 5hmC level in the gene-body region was abundant during the other stages. (B) 5hmC distribution in the gene-body region of stage-specific DEGs at each stage. The red line represents the 5hmC distribution at each stage, and the blue line represents the 5hmC distribution at the other stages. (C) Snapshot of stage-specific DNA hypomethylation at each stage of early T-cell development. (D) Snapshot of stage-specific DNA hyperhydroxymethylation at each stage of early T-cell development. The abundance of methylation and hydroxymethylation was calculated from non-overlapping 200-bp bins spanning each stage.
Mol. Cells 2018;41:953~963 https://doi.org/10.14348/molcells.2018.0213
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