Molecules and Cells

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Fig. 1.

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Fig. 1. In total, 2,688 DEGs were selected based on a log2FC(RPKM) > 2 and p-value < 0.05. (A) Overall patterns of gene expression changes across the stages of the T-cell development process. The most dramatic changes occurred from DN4 to DP (11.37%), whereas fewer gene expression changes were observed from DN3 to DN4 (2.81%). Moderate gene expression changes occurred from DP to CD4 (9.46%) and DP to CD8 (6.87%). (B) Hierarchical clustering of gene expression patterns across developmental stages. (C) Hierarchical clustering of gene expression patterns of differentially expressed transcription factors across developmental stages. Major transcription factors during each stage. (D) Stage-specific gene expression at each stage (DN3 to CD4 and CD8).
Mol. Cells 2018;41:953~963 https://doi.org/10.14348/molcells.2018.0213
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