Molecules and Cells

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Fig. 2.

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Fig. 2. (A) HUVECs were treated with oleanolic acid at the indicated doses. Cell viability was determined by MTT assay. Note that oleanolic acid at any doses showed no toxicity in HUVECs. The bar graph represents the means ± SD (n = 4). (B) VEGF-induced VEGFR-2 phosphorylation (pVEGFR-2) or Erk1/2 phosphorylation (pErk1/2) in HUVECs with or without the pretreatment of oleanolic acid (OA) at the indicated doses was examined by western blot analysis. Erk1/2 and β-actin were used as controls. (C) HUVECs were treated with VEGF (20 ng/ml) and/or oleanolic acid (10 μM). The phosphorylation levels of VEGFR-2 (pVEGFR-2) and Erk1/2 (pErk1/2) were examined by western blot analysis. (D) Quantitative densitometric analysis of western blots in panel (C). The results are fold increases versus the value of the control. The bar graph represents the means ± SD (n = 3). * P < 0.05 between the two values.
Mol. Cells 2018;41:771~780 https://doi.org/10.14348/molcells.2018.0207
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