Molecules and Cells

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Fig. 5.

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Fig. 5. (A) Staurosporine (STS) treatment for the indicated time points downregulated MCL-1 expression. Western blot analysis was performed for MCL-1, BCL-xL, and BAX protein expression over a 6-h time course following treatment with STS. After 4 h of treatment, STS significantly decreased protein levels of MCL-1 but not BCL-xL or BAX. (B) Quantitative reverse transcription PCR (qRT-PCR) analysis of MCL-1 during STS treatment. (C) Effects of the proteasome inhibitor MG132 on MCL-1 degradation. (D) Western blot analysis of hTERT-expressing HEK 293T/17 cells after STS treatment. There were no significant changes in MCL-1 protein levels by hTERT overexpression.
Mol. Cells 2018;41:684~694 https://doi.org/10.14348/molcells.2018.0206
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