Molecules and Cells

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Fig. 3.

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Fig. 3. (A, B) Co-IP of hTERT and BAD or BECN1. hTERT can bind to BH3-only proteins BAD and BECN1. (C) Domain mapping of the interaction between hTERT and BECN1. A schematic representation of BECN1 domains is shown at the top. HEK 293T/17 cells were transfected with the indicated plasmids, followed by co-IP assays with anti-FLAG beads. The indicated antibodies were used to detect bound proteins eluted from the beads. The coiled-coil domain of BECN1 is important for hTERT interaction. CCD, coiled-coil domain; ECD, evolutionarily conserved domain.
Mol. Cells 2018;41:684~694
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