Molecules and Cells

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Fig. 4.

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Fig. 4. (Top) A central role of UBE2O for erythropoiesis. UBE2O confers the erythroid differentiation through promoting the ubiquitination of free ribosomal proteins (1) and unassembled α-globin (2) and thereby remodeling the differentiation-linked proteome. (Bottom) An oncogenic role of UBE2O in cancer. UBE2O ubiquitinates and promotes ubiquitination and degradation of wild-type MLL but not MLL fusion proteins in MLL leukemia (1). Furthermore, UBE2O promotes mTOR− and HIF1α–mediated tumorigenesis through selectively targeting the AMPKα2 protein (2).
Mol. Cells 2018;41:168~178
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